October 2-4 2023 - Grenoble, France
Symposium "Signaling through Chromatin"
from molecules to ecosystems
20 invited speakers. 20 selected short talks.
In October 2023, a 3 days symposium focused on “Signaling through Chromatin: from molecules to ecosystems” will cover innovative aspects of chromatin and epigenetics, from the atomic to cellular, organismal, and population scales.
The symposium will be comprised of eight sessions, exploring chromatin dynamics and its link to several DNA and RNA-based processes such as transcription, DNA replication, repair and recombination. Finally, dedicated sessions will feature the translational implications of epigenetic studies and the development of “epi-drugs”.
The symposium will present multiple approaches, such as quantitative proteomics, metabolomics, structural biology, single-cell epigenomics and population studies in different model organisms, from yeast to plants and mammals, including 3D culture models.
The registration deadline was July 31, 2023. However, you may still submit a late application, which the organizers will consider if there is still room available.
Registration fees are:
- Academic students : 200€
- Academic scientist (post doc, staff scientist) : 260€
- Industry : 1,000€
Registration fees include: conference participation, coffee breaks, Wine & Cheese dinner on first day (Oct. 2nd), Lunch on second day (Oct. 3rd).
These costs do not include travel / accommodation costs lunch on the first and last day, or gala dinner on second day (please reserve the gala dinner using the appropriate field in the registration platform).
Program
The following speakers have already confirmed their attendance:
- Shelley Berger – University of Pennsylvania, USA
- Clara Bourbousse – IBENS, Paris, France
- Chris Bowler – IBENS, Paris, France
- Sandra Duharcourt – Institut Jacques Monod, Paris, France
- Olivier Espeli – CIRB – Collège de France, Paris, France
- Katharina Gapp – ETH, Zurich, Switzerland
- Anja Groth – Novo Nordisk Foundation, Copenhagen, Denmark
- Petra Hajkova – London Institute of Medical Sciences, UK
- Janosch Hennig – EMBL, Heidelberg, Germany
- Saadi Khochbin – IAB, Grenoble, France
- Rob Martienssen – Cold Spring Harbor Laboratory, USA
- Christoph Müller – EMBL, Heidelberg, Germany
- Magnus Nordborg – GMI, Vienna, Austria
- Dónal O’Carroll – Edinburgh, UK
- Marieke Oudelaar – Max Planck Institute, Göttingen, Germany
- Charlotte Proudhon – IRSET, Rennes, France
- Claire Rougeulle – Univ. Paris Cité, France
- Céline Vallot – Institut Curie, Paris, France
- Jérémie Vidal-Dupiol – IFREMER, Montpellier, France
- Jonathan Weitzman – Univ. Paris Cité, France
- Jan Żylicz – Univ. Copenhagen, Denmark
The detailed program is presented below or can be downloaded (pdf version).
1:00 pm – 1:30 pm Arrival and registration
1:30 pm – 1:45 pm Welcome address by Jérôme Govin
Keynote 1. Plenary lecture – Chaired by Jérôme Govin
1:45 pm – 2:30 pm Shelley L . Berger (USA)
Title to be announced
Session 1. Structure biology of epigenetic complexes – Chaired by Jan Kadlec
2:30 pm – 2:55 pm Christoph Müller (Germany)
Roles of RNA polymerase I and III transcription complexes in gene expression and genome organization
2:55 pm – 3:10 pm Camille Sayou (France)
Tale of a reader domain that preferred DNA over histone tails
3:10 pm – 3:35 pm Janosh Hennig (Germany)
Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless during Drosophila dosage compensation
3:35 pm – 3:50 pm Luisa Felgines (France).
Evolution of the CLASSY-RNA polymerase IV complex that silences transposons in plants through small RNA biogenesis
3:50 pm – 4:05 pm Michal Razew (France)
Integrative model of the fully assembled Integrator complex bound to a transcription factor
4:05 pm – 4:30 pm Coffee break
Session 2. Chromatin / nuclear structure and RNA – Chaired by Marco Marcia
4:30 pm – 4:55 pm Dónal O’Carroll (UK)
Safeguarding immortality
4:55 pm – 5:10 pm Tristan Escure (France)
The HUSH-SETDB1-MORC2 epigenetic repressor complex controls heterochromatin marks associated to the silencing of a herpesvirus genome
5:10 pm – 5:35 pm Marieke Oudelaar (Germany)
In vitro reconstitution of chromatin domains
5:35 pm – 5:50 pm Auriane Rakitch (France)
Conserved Erh1 protein orchestrates Mmi1 YTH-guided multi-modal mRNA silencing
5:50 pm – 6:10 pm Mini break
6:10 pm – 6:35 pm Claire Rougeulle (France)
To be inactive or not: an eXISTential question
6:35 pm – 6:50 pm Antonia Hauth (Germany)
Escape from X inactivation and 3D chromosome topology: cause or consequence?
6:50 pm – 7:05 pm Vangeli Geshkovski (France)
Chromatin switches in plants: Molecular mechanisms of the ULTRAPETALA1 protein
7:05 pm – 7:15 pm Sponsor Talk Active Motif
7:15 pm – 10:00 pm Poster session
Session 3. Epigenetic mechanisms in model organisms – Chaired by Ramesh Pillai
9:00 am – 9:25 am Sandra Duharcourt (France)
Epigenetics and genome dynamics in the ciliate Paramecium
9:25 am – 9:40 am Jeremy Berthelier (Japan)
Epigenetic mechanisms regulate gene-transposon transcripts affecting stress responses in Arabidopsis thaliana
9:40 am – 10:05 am Olivier Espeli (France)
The bacterial chromatin: chromosome and cell cycle organizer
10:05 am – 10:20 am Francesca Masoni (Switzerland)
Systematic assessment of ISWI subunits reveals that NURF creates local accessibility for proper CTCF function
10:20 am – 10:35 am Martina Shahinas (France)
In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming
10:35 am – 10:45 am Sponsor Talk Diagenode
10:45 am – 11:15 am Coffee break
Session 4. Epigenetics in development – Chaired by Ana Boskovic
11:15 am – 11:40 am Petra Hajkova (UK)
Passage of epigenetic information through the germline: the tales of erasure and long term maintenance
11:40 am – 11:55 am Antoine Molaro (France)
(epi)Genetic Conflicts Shaping Mammalian Reproduction
11:55 am – 12:20 pm Saadi Khochbin (France)
NME1/2 mediate epigenetic reprogramming of liver cells in response to a high-fat diet
12:20 pm – 12:35 pm Julie Cocquet (France)
The H3K79 methyltransferase DOT1L has pleiotropic regulatory effects during spermatogenesis
12:35 pm – 12:50 pm Guillermo Orsi (France)
Liquid crystal-like chromatin to fit the cricket genome into the sperm nucleus
12:50 pm – 2:00 pm Lunch
Keynote 2. Plenary lecture – Chaired by André Verdel
2:00 pm – 2:45 pm Rob Martienssen (USA)
Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation
Session 5. Epigenetic deregulations in cancer – Chaired by Julia Fuchs
2:45 pm – 3:10 pm Céline Vallot (France)
TBA
3:10 pm – 3:25 pm Débora Parrine (Sweden)
A new HDAC regulator with a critical role in differentiation and development
3:25 pm – 3:50 pm Anja Groth (Denmark)
TBA
3:50 pm – 4:05 pm Jumana Alhaj Abed (USA)
Investigating how paired parental chromosome organization shapes gene function
4:05 pm – 4:35 pm Coffee break
Session 6. Systems epigenetics – Chaired by François Parcy
4:35 pm – 5:00 pm Jan Żylicz (Denmark)
TBA
5:00 pm – 5:15 pm José Antonio Sanchez Villanueva (France)
Modelling the role of EZH2 in Acute Promyelocytic Leukaemia resistance to Retinoic Acid therapy
5:15 pm – 5:40 pm Katharina Gapp (Switzerland)
Stress signalling signatures in sperm
5:40 pm – 6:05 pm Chris Bowler (France)
Epigenetics in the cold dark Arctic Ocean
6:05 pm – 7:00 pm Gala Diner : walk & Bastille Telepherique
7:00 pm – 10:00 pm Gala Diner at O2 restaurant (scenic view)
Session 7. Population epigenetics and epidemiology – Chaired by André Verdel
9:00 am – 9:25 am Magnus Nordborg (Austria)
The genetics of epigenetics
9:25 am – 9:40 am Pierre Baduel (France)
Mechanisms, extent, and impact of natural epigenetic variation at transposable element sequences in Arabidopsis thaliana
9:40 am – 10:05 am Charlotte Proudhon (France)
Non-invasive multi-cancer diagnosis using DNA hypomethylation of LINE-1 retrotransposons
10:05 am – 10:35 am Coffee break
Session 8. Environmental epigenetics – Chaired by Vincent Colot
10:35 am – 11:00 am Jérémie Vidal-Dupiol (France)
Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific Oyster Mortality Syndrome
11:00 am – 11:15 am Tatjana Lumpp (Germany)
Arsenite-mediated epigenetic disruption of histone acetylation in DNA repair genes within lung epithelial cells
11:15 am – 11:40 am Jonathan Weitzman (France)
Chromatin dynamics in host-parasite interactions
11:40 am – 11:55 am Fatema Zahra Rashid (Netherlands)
Regulation of proVWX transcription by local chromatin remodelling
11:55 am – 12:20 pm Clara Bourbousse (France)
TBA
12:20 pm – 12:30 pm Closing remarks by Vincent Colot
12:30 pm – 2:00 pm Lunch buffet, departure
Date & venue
The symposium will start early afternoon of October 2nd and end at the end of the morning of October 4th 2023.
It will be located at Minatec Events Congress Center, an exceptional venue.