We have the pleasure to announce that Cristel Carles (PCV, iRTSV) invited Aline Probst in Grenoble. She will present her work on March 10 2015 at 1pm at the IAB.
Heterochromatin organization and dynamics during development
By Aline Probst
Génétique, Reproduction et Développement, UMR CNRS 6293, Clermont Université, INSERM U1103, 24 Avenue des Landais, BP 80026, 63171 Aubière Cedex, France
In eukaryotes, nuclear DNA is packaged into chromatin. The organization of chromatin both at the level of the nucleosome and higher-order nuclear structure impacts all processes operating on DNA such as transcription, replication and repair. Heterochromatin domains, defined as chromosomal domains that remain condensed throughout the cell cycle, are critical for genome integrity given their role in chromosome segregation and transcriptional control of transposable and repetitive DNA elements. Heterochromatin domains need to be stably maintained to assure their vital function, but likewise require a certain plasticity to allow their dynamic reorganization during reprogramming and development.
Combining fluorescence in situ hybridization with functional and genetic studies in plants and mammals we have gained insight into the role of non-coding RNA and the incorporation of specific histone variants in the initial formation of heterochromatin as well as its organization into chromocenter structures during development.