Seminar: iRTSV, Thursday Oct 2nd, 2pm. Hi-C and 3D reconstruction

Dear all,

Please find below an announcement for a seminar which will probably interest our community. It will be after the Chromatin Meeting, this Thursday Oct 02, on the iRTSV campus, at 2pm.

You will need a CEA pass to reach the conference room. Please contact Odile Rossignol to get it (odile.rossignol@cea.fr, 04 38 78 45 63).

See you all Thursday!
Best,
The organization committee (Jan, André, Jérôme)

Reconstructing the 3D architecture of the genome
Jean-Philippe Vert, Institut Curie, Mines ParisTech
Thursday Oct 2nd 2014, 2 pm, Room C3.104
Recent technological advances allow the measurement, in a single Hi-C experiment, of the frequencies of physical contacts among pairs of genomic loci at a genome-wide scale. The next challenge is to infer, from the resulting DNA–DNA contact maps, accurate 3D models of how chromosomes fold and fit into the nucleus. I will present PASTIS, a new method to infer a consensus model of DNA structure from Hi-C data. I will also discuss how DNA structure is related to gene regulation in Plasmodium falciparum, the parasite responsible for malaria.